Endocrine Abstracts

Adult Growth Hormone Deficiency (GHD) is a condition characterized by low grade chronic inflammation; increased levels of free light chains of immunoglobulins have been described; moreover, it shares some features with metabolic syndrome (MetS), including insulin resistance and oxidative stress, but with a different pattern of antioxidant response. Finally, it is known that GH, directly or via IGF-1 activity, influences many aspects of immune response; both humoral and cellula...

ObjectivePolicystic ovary syndrome (PCOS) is a multifactorial disease characterized by reproductive and metabolic impairments. PCOS patients could present anovulation, hirsutism and infertility as well as higher prevalence of metabolic syndrome, glucose intolerance and diabetes. Insulin-resistance (IR) together with hyperandrogenism represent the main players, with reciprocal influences in a vicious circle: insulin promotes androgen secretion in thecal c...